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    nyap2b neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 100535812, updated on 11-Apr-2024

    Summary

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    Official Symbol
    nyap2bprovided by ZNC
    Official Full Name
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-169
    See related
    Ensembl:ENSDARG00000093357 AllianceGenome:ZFIN:ZDB-GENE-070705-169
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-273k1.2
    Summary
    Predicted to be involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase signaling. Orthologous to human NYAP2 (neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (5735579..5776109, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (5823361..5864231, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene CWC25 spliceosome associated protein homolog Neighboring gene somatostatin 2 Neighboring gene solute carrier family 35 member D1b Neighboring gene mesoderm induction early response 1b, transcriptional regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      5735579..5776109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297225.3 → XP_009295500.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2-like isoform X2

      UniProtKB/TrEMBL
      A0A8M3AYW4
      Conserved Domains (3) summary
      pfam08017
      Location:540 → 810
      Fibrinogen_BP; Fibrinogen binding protein
      pfam15439
      Location:15 → 354
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:747 → 939
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    2. XM_003197820.5 → XP_003197868.2  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2-like isoform X1

      UniProtKB/TrEMBL
      A0A8M1RN71, F1QW26
      Related
      ENSDARP00000122586.2, ENSDART00000133851.3
      Conserved Domains (3) summary
      pfam08017
      Location:582 → 852
      Fibrinogen_BP; Fibrinogen binding protein
      pfam15439
      Location:52 → 396
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:784 → 981
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    Nucleotide Protein
    Heading Accession and Version

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